Hydroflumethiazide

Indications
 Oral
Oedema
Adult: 50-100 mg daily in 1-2 divided doses, may reduce to 25-50 mg on alternate days or intermittently. Max: 200 mg daily.
Oral
Hypertension
Adult: Initial dose: 12.5 mg daily. Usual dose: 25-50 mg daily alone or in conjunction with other antihypertensives.
Child: 1 mg/kg daily, may reduce dose for maintenance.
Contraindications
 Severe hepatic or renal impairment; anuria; Addison's disease; hypercalcaemia. Pregnancy and lactation.
Warnings / Precautions
 Fluid and electrolyte disturbances; hepatic cirrhosis; gout; DM. Elderly; severe heart failure; renal or hepatic impairment. Monitor blood glucose concentrations in patients taking antidiabetics.
Adverse Reactions
 Electrolyte imbalance; hyperglycaemia; gout; dry mouth; thirst; weakness; muscle pain and cramp; seizures; hypotension; GI disturbances; anorexia; sialadenitis; headache; impotence; yellow vision; hypersensitivity reactions; cholestatic jaundice; pancreatitis; blood dyscrasias; glycosuria; dizziness; photosensitivity reactions, postural hypotension, paraesthesia.
Overdose Reactions
 Lethargy, nausea, weakness and electrolyte imbalance, possibly progress to coma within a few hr with minimal depression of respiratory and CV function and with no evidence of dehydration or serum electrolyte changes. GI irritation and hypermotility, temporary elevation of the BUN, serum electrolyte changes (e.g. hypokalemia, hypochloremia, hyponatremia) may occur in renally impaired patients. Empty stomach by inducing vomiting with ipecac syrup If patient is conscious. Cathartics should not be admin as they may promote loss of fluid and electrolytes. Supportive and symptomatic treatment with monitoring of serum electrolytes, renal, respiratory, and CV function. Replace fluid and electrolytes where necessary.
Drug Interactions
 Digitalis glycosides; drugs that prolong QT interval; other antihypertensives; competitive muscle relaxants; pressor amines; corticosteroids, corticotrophin; β2-agonists, α-blockers; ACE inhibitors; NSAIDs; alcohol, barbiturates; opioids; lithium; Allopurinol; tetracyclines; carbenoxolone; hypoglycaemics.
See Below for More hydroflumethiazide Drug Interactions
Mechanism of Actions
 Hydroflumethiazide reduces the reabsorption of electrolytes from the renal tubules, hence increasing the excretion of sodium and chloride ions and consequently of water. It also reduces the glomerular filtration rate.
Onset: 2 hr.
Duration: 24 hr.
Absorption: Incompletely but fairly rapidly absorbed from the GI tract.
Excretion: Excreted in the urine.
ATC Classification
 C03AA02 - hydroflumethiazide ; Belongs to the class of low-ceiling thiazide diuretics.
Available As
  • Hydroflumethiazide 25 mg

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