Human Chorionic Gonadotrophin

Indications
 Intramuscular
Prepubertal cryptorchidism in males
Adult: 500-4000 u injected 3 times wkly. Treatment should continue for 1-2 mth after testicular descent.
Child:
Intramuscular
Male infertility due to hypogonadotrophic hypogonadism
Adult: 500-4000 u injected 2-3 times wkly.
Child:
Intramuscular
Anovulatory infertility
Adult: Single dose of 5000-10,000 u. Up to 3 repeated injections of up to 5000 u each may be given within the following 9 days to prevent corpus luteum insufficiency.
Intramuscular
Delayed puberty associated with hypogonadism in males
Adult: Male: Initially, 500-1500 u twice a wk titrated against plasma-testosterone concentration.
Contraindications
 Hypersensitivity; precocious puberty, prostatic carcinoma or other androgenic dependent neoplasm. Pregnancy and lactation.
Warnings / Precautions
 Discontinue therapy if signs of precocious puberty are seen in patients treated for cryptorchidism. Patients with cardiac or renal disease, epilepsy, migraine or asthma.
Adverse Reactions
 Headache, irritability, restlessness, depression, fatigue, oedema; precocious puberty, gynaecomastia; pain at Inj site; enlargement of preexisting ovarian cysts and possible rupture; arterial thromboembolism; shock; abdominal pain.
Potentially Fatal: Ovarian hyperstimulation syndrome (OHSS).
Mechanism of Actions
 Chorionic Gonadotrophin is a polypeptide hormone produced by the human placenta. It stimulates the production of gonadal steroid hormones by inducing interstitial cells (Leydig cells) of the testis to produce androgens and the corpus luteum of the ovary to produce progesterone.
Absorption: Peak concentrations after 6 hrs (IM).
Distribution: Mainly in the gonads.
Excretion: Via the urine (10-12% of IM dose within 24 hrs). Elimination half-life: 6-11 hrs (initial phase), 23-38 hrs (terminal phase).
ATC Classification
 G03GA01 - chorionic gonadotrophin ; Belongs to the class of gonadotropins. Used as ovulation stimulants.
Available As
  • Human Chorionic Gonadotrophin 1000 iu
  • Human Chorionic Gonadotrophin 10000 iu
  • Human Chorionic Gonadotrophin 150 iu
  • Human Chorionic Gonadotrophin 1500 iu
  • Human Chorionic Gonadotrophin 2000 iu
  • Human Chorionic Gonadotrophin 250 mcg
  • Human Chorionic Gonadotrophin 5000 iu
  • Human Chorionic Gonadotrophin 75 iu

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