Flurbiprofen

Indications
 Oral
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: 150-200 mg daily in divided doses, increased to 300 mg daily in acute or severe conditions if necessary.
Oral
Dysmenorrhoea
Adult: Initially, 100 mg followed by 50-100 mg every 4-6 hr. Max: 300 mg/day.
Oral
Sore throat
Adult: 1 lozenge (8.75 mg) every 3-6 hr. Max: 5 lozenges/day. Max treatment duration: 3 days.
Child: <12 yr: Not recommended.
Ophthalmic
Prophylaxis of miosis during ocular surgery
Adult: As sodium: Instill 1 drop of a 0.03% solution into the eye every 30 minutes starting 2 hr before and ending not < 30 minutes before the surgery.
Ophthalmic
Postoperative ocular inflammation
Adult: Instill 1 drop of a 0.03% solution into the eye 4 times daily for 1-3 wk starting at 24 hr after surgery.
Contraindications
 Peptic ulcer, GI haemorrhage, asthma, bronchospasm, rhinitis, angioedema, hypersensitivity; aspirin intolerance; pregnancy (3rd trimester); lactation.
Warnings / Precautions
 Hypertension; impaired renal function.
Adverse Reactions
 Fluid retention, oedema; allergic nephritis, allergic reactions; GI upsets; dizziness, tinnitus, blurring of vision; local irritation, transient burning and stinging (ophthalmic).
Potentially Fatal: Peptic ulceration, haemorrhage and perforation.
Drug Interactions
 Increases serum concentrations of digoxin; may enhance effects of anticoagulants.
See Below for More flurbiprofen Drug Interactions
Mechanism of Actions
 Flurbiprofen inhibits prostaglandin synthesis by decreasing the activity of cyclooxygenase resulting in reduced prostaglandin levels. It is also a potent inhibitor of platelet aggregation.
Onset: 1-2 hrs.
Absorption: Readily absorbed from the GIT (oral); peak plasma concentrations after 1-2 hrs.
Distribution: Small amounts enter breast milk. Protein-binding: 99%
Metabolism: Hepatic via hydroxylation and conjugation.
Excretion: Urine (as metabolites); 3-6 hrs (elimination half-life).
Administration
 Should be taken with food.
Storage Conditions
 Ophthalmic: Store at 15-25°C. Oral: Store at 15-25°C.
ATC Classification
 M01AE09 - flurbiprofen ; Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products.
M02AA19 - flurbiprofen ; Belongs to the class of non-steroidal antiinflammatory preparations for topical use. Used in the treatment of joint and muscular pains.
S01BC04 - flurbiprofen ; Belongs to the class of non-steroidal antiinflammatory agents. Used in the treatment of inflammation of the eye.
Storage
 Ophthalmic: Store at 15-25°C. Oral: Store at 15-25°C.
Available As
  • Flurbiprofen Sodium 0.03%
  • Flurbiprofen 0.03%
  • Flurbiprofen 0.03% w/v
  • Flurbiprofen Sodium 0.03% w/v
  • Flurbiprofen Sodium 0.3 mg
  • Flurbiprofen Sodium 0.3%
  • Flurbiprofen Sodium 0.3% w/v
  • Flurbiprofen 0.3% w/v
  • Flurbiprofen 100 mg
  • Flurbiprofen 200 mg
  • Flurbiprofen 5% w/w
  • Flurbiprofen 50 mg

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