Finasteride

Indications
Oral
Benign prostatic hyperplasia
Adult: 5 mg once daily for ≥6 mth, if necessary.
Oral
Male pattern baldness
Adult: 1 mg once daily.
Contraindications
Children, exposure of pregnant women to finasteride either via direct contact with crushed tab or through semen of male sexual partners who are taking finasteride; pregnancy, lactation.
Warnings / Precautions
Undiagnosed prostate cancer, liver dysfunction, obstructive uropathy.
Adverse Reactions
Gynaecomastia, decreased libido, impotence, reduction in the volume of ejaculate, testicular pain. Hypersensitivity reactions e.g. swelling of lips and face, urticaria, rashes.
Lab Interactions
May mask serum markers (PSA) for prostate cancer.
Food Interactions
Food may delay the rate and reduce the extent of oral absorption
Mechanism of Actions
Finasteride is a competitive inhibitor of the enzyme 5-α reductase which converts testosterone to dihydrotestosterone (DHT), thus resulting in decreased serum levels of DHT.
Absorption: Absorbed from the GI tract (oral); peak plasma concentrations after 1-2 hr.
Distribution: Protein-binding: 90%.
Metabolism: Hepatic.
Excretion: Urine and faeces (as metabolites); <60 yr: 6 hr; >70 yr: 8 hr (elimination half-life).
Administration
May be taken with or without food.
Storage Conditions
Oral: Store at 15-30°C.
ATC Classification
D11AX10 - finasteride ; Belongs to the class of other dermatologicals.
G04CB01 - finasteride ; Belongs to the class of testosterone-5-alpha reductase inhibitors. Used in the treatment of benign prostatic hypertrophy.
Storage
Oral: Store at 15-30°C.
Available As
  • Finasteride 1 mg
  • Finasteride USP 1 mg
  • Finasteride 2.5 mg
  • Finasteride 5 mg
  • Finasteride USP 5 mg
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