Fexofenadine

Indications
 Oral
Seasonal allergic rhinitis
Adult: 120 mg once daily.
Child: 6-11 yr: 30 mg bid.
Renal impairment: Adult: Initially, 60 mg once daily. Child: 6 mth-<2 yr: 15 mg once daily and 2-11 yr: 30 mg once daily.
Oral
Chronic idiopathic urticaria
Adult: 180 mg once daily.
Child: 6 mth-<2 yr: 15 mg bid; ≥2 yr: 30 mg bid.
Renal impairment: Adult: Initially, 60 mg once daily. Child: 6 mth-<2 yr: 15 mg once daily and 2-11 yr: 30 mg once daily.

Special Populations: In patients with decreased renal function: 60 mg once daily.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Renal impairment. Pregnancy, lactation; children <6 yr.
Adverse Reactions
 Viral infection (cold/flu); headache, dizziness, drowsiness, fatigue; nausea, dyspepsia, dysmenorrhoea.
Drug Interactions
 Co-admin with ketoconazole or erythromycin may increase plasma levels of fexofenadine. May increase adverse effects of other anticholinergics and CNS depressants. May increase arrhythmogenic effect of antipsychotic agents (phenothiazines); avoid concurrent usage. May reduce the efficacy of betahistine. Pramlintide may increase the anticholinergic effect of fexofenadine. Bioavailability may be increased by verapamil. Efficacy may be reduced by rifampin.
See Below for More fexofenadine Drug Interactions
Food Interactions
 Decreased levels with St John's wort. Fruit juice (apple, grapefruit, orange) may reduce bioavailability of fexofenadine by about 36%. Possible increased risk of sedation with ethanol.
Mechanism of Actions
 Fexofenadine, an active metabolite of terfenadine, is a competitive peripheral histamine H1-receptor antagonist on effector cells in the GI tract, blood vessels and respiratory tract.
Absorption: Absorbed rapidly from the GI tract (oral); peak plasma concentrations after 2-3 hr.
Distribution: Enters breast milk. 60-70% bound to plasma proteins.
Metabolism: Intestinal mucosa (5% of total dose); hepatic (0.5-1.5% of dose).
Excretion: Mainly via faeces, via urine (10% of dose); 14 hr (elimination half-life; may be prolonged in renal impairment).
Administration
 Should be taken on an empty stomach. (Take before meals. Do not take w/ fruit juice. )
Storage Conditions
 Oral: Store at 20-25°C.
ATC Classification
 R06AX26 - fexofenadine ; Belongs to the class of other antihistamines for systemic use.
Storage
 Oral: Store at 20-25°C.
Available As
  • Fexofenadine 120 mg
  • Fexofenadine Hcl 120 mg
  • Fexofenadine 180 mg
  • Fexofenadine Hcl 180 mg
  • Fexofenadine 30 mg
  • Fexofenadine 60 mg
  • Fexofenadine Hcl 60 mg

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