Indications |
Oral Iron-deficiency anaemia Adult: Treatment: 400-600 mg daily in divided doses. Prevention: 200 mg daily. Child: Treatment: <6 yr or <22 kg: Not recommended. 6-12 yr: >22 kg: 200 mg daily; >44 kg: 200 mg bid >66 kg: 200 mg tid. |
Contraindications |
Patients receiving repeated blood transfusions; anaemia not due to iron deficiency. |
Warnings / Precautions |
Elderly. Avoid admin for >6 mth except in patients with continuous bleeding. Avoid concomitant oral and parenteral iron therapy. Iron-storage or iron-absorption diseases (e.g. haemochromatosis), haemoglobinopathies); existing GI diseases (e.g. inflammatory bowel disease, intestinal strictures, diverticulae, peptic ulcer disease, enteritis or ulcerative colitis). Liquid preparations may stain teeth. |
Adverse Reactions |
GI irritation, abdominal pain and cramps, nausea, vomiting, constipation, diarrhoea, dark stool and discoloration of urine; heartburn. |
Overdose Reactions |
Symptoms: Nausea, vomiting, abdominal pain, diarrhoea of green or tarry stools, haematemesis, seizures, drowsiness, metabolic acidosis, hepatic dysfunction, renal failure, coma. Treatment: Empty stomach contents by gastric lavage. In severe toxicity, IV desferrioxamine may be given. Treatment is supportive. Haemodialysis is unlikely to be useful. |
Drug Interactions |
Decreased iron absorption with antacids, colestyramine, trientine, proton pump inhibitors. Decreased absorption of both iron and tetracycline when admin together. Delayed response to iron in patients on systemic chloramphenicol. Reduced efficacy of levothyroxine with iron. Decreased absorption of cefdinir, bisphosphonates, entacapone, flouroquinolones, levodopa, methyldopa and penicillamine. See Below for More ferrous sulfate Drug Interactions |
Lab Interactions |
May interfere with tests used for detection of occult blood as iron preparations may colour the faeces black. May cause false-positive guaiac test for blood. |
Food Interactions |
Absorption may be decreased by wholegrains, tea, coffee, eggs and milk. Increased absorption with vitamin C. |
Mechanism of Actions |
Ferrous sulfate facilitates O2 transport via haemoglobin. It is used as iron source as it replaces iron found in haemoglobin, myoglobin and other enzymes. Onset: Oral: 3-10 days. Absorption: Duodenum and upper jejunum: 10% absorption after oral admin in persons with normal serum iron stores; 20-30% absorption in those with inadequate iron stores. Excretion: Via urine, sweat, sloughing of the intestinal mucosa and menstruation. |
Administration |
Should be taken on an empty stomach. (Best taken on an empty stomach. May be taken w/ meals to reduce GI discomfort.) |
Storage Conditions |
Oral: Store below 25°C. |
ATC Classification |
B03AA07 - ferrous sulfate ; Belongs to the class of oral iron bivalent preparations. Used in the treatment of anemia. B03AD03 - ferrous sulfate ; Belongs to the class of iron in combination with folic acid. Used in the treatment of anemia. |
Storage |
Oral: Store below 25°C. |
Available As |
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Ferrous Sulphate
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Ferrous Sulphate Containing Brands
Ferrous Sulphate is used in following diseases
Drug - Drug Interactions of Ferrous Sulphate
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