Dicyclomine (Dicycloverine)

Indications
Oral
Gastrointestinal tract spasm
Adult: 10-20 mg tid.
Child: 2-12 yr: 10 mg tid; 6 mth-2 yr: 5-10 mg 3-4 times daily.
Elderly:
Intramuscular
Gastrointestinal tract spasm
Adult: 20 mg 4 times a day given only for 1-2 days. Replace with oral therapy as soon as possible.
Contraindications
Intestinal obstruction; intestinal atony; myasthenia gravis; glaucoma; reflux oesophagitis; infants <6 mth; lactation.
Warnings / Precautions
Hepatic or renal disease, urinary retention, paralytic ileus, hyperthyroidism, hypertension, congestive heart failure, cardiac tachyarrhythmia, children, elderly, pregnancy.
Adverse Reactions
Difficulty in accommodation, exacerbation of glaucoma; tachycardia, palpitations, arrhythmias; urinary retention; restlessness; confusion, excitement, hallucination and delirium.
Potentially Fatal: Respiratory arrest in infants <10 wk.
Overdose Reactions
Symptoms: headache, dizziness, nausea, dry mouth, difficulty in swallowing, dilated pupils and hot dry skin. Management: treatment is symptomatic. Reduce drug absorption by emetics or gastric lavage.
Drug Interactions
Antagonise the effect of drugs that affect GI motility e.g. metoclopramide. Absorption affected by concurrent admin with antacids.
See Below for More dicycloverine hydrochloride Drug Interactions
Mechanism of Actions
Dicycloverine HCl relieves smooth muscle spasm in the GI and urinary tract. This effect is partly due to antimuscarinic action and partly direct action on the smooth muscle.
Administration
Dicycloverine: May be taken with or without food. (May be taken before or after meals.)
Storage Conditions
Intramuscular: Store below 30°C. Oral: Store below 30°C.
ATC Classification
A03AA07 - dicycloverine ; Belongs to the class of synthetic anticholinergics, esters with tertiary amino group. Used in the treatment of functional bowel disorders.
Storage
Intramuscular: Store below 30°C. Oral: Store below 30°C.
Available As
  • Dicyclomine (Dicycloverine) 1 mg
  • Dicyclomine (Dicycloverine) 10 mg
  • Dicyclomine Hydrochloride 10 mg
  • Dicyclomine (Dicycloverine) 15 mg
  • Dicyclomine Hydrochloride 15 mg
  • Dicyclomine Hydrochloride 20 mg
  • Dicyclomine (Dicycloverine) 20 mg
  • Dicyclomine (Dicycloverine) 325 mg
  • Dicyclomine (Dicycloverine) 5 mg
  • Dicyclomine Hydrochloride 5 mg
  • Dicyclomine (Dicycloverine) 50 mg
  • Dicyclomine (Dicycloverine) 6 mg
  • Dicyclomine (Dicycloverine) 7.5 mg
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