Indications |
Oral Osteoarthritis Adult: 50 mg bid.
Special Populations: In patients with CrCl <30 mL/min, doses should be halved. |
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Contraindications |
Pregnancy, lactation. Hypersensitivity to anthraquinone derivatives. | ||||
Warnings / Precautions |
Renal impairment. Monitor CBC, LFT and urinalysis every 6 mth. | ||||
Adverse Reactions |
Diarrhoea, epigastric pain, nausea, vomiting, intense yellow colouring of urine. | ||||
Overdose Reactions |
Symptoms: diarrhoea. Management: symptomatic treatment. | ||||
Drug Interactions |
Decreased absorption with aluminium and/or magnesium hydroxide antacids. Increased risk of diarrhoea with laxatives, antibiotics. Avoid co-admin with fibres and phytates. See Below for More diacerein Drug Interactions |
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Mechanism of Actions |
Diacerein is an anthraquinone derivative that has been used in osteoarthritis. It is thought to act via inhibition of interleukin-1β. | ||||
Administration |
Should be taken with food. (Take w/ or immediately after meals.) |
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Storage Conditions |
Oral: Store at 15-25°C. | ||||
ATC Classification |
M01AX21 - diacerein ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products. | ||||
Storage |
Oral: Store at 15-25°C. | ||||
Available As |
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Diacerein
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Diacerein Containing Brands
Diacerein is used in following diseases
Drug - Drug Interactions of Diacerein
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