Diacerein

Indications
Oral
Osteoarthritis
Adult: 50 mg bid.
CrCl (ml/min)Dosage Recommendation
<3025 mg daily.


Special Populations: In patients with CrCl <30 mL/min, doses should be halved.
Contraindications
Pregnancy, lactation. Hypersensitivity to anthraquinone derivatives.
Warnings / Precautions
Renal impairment. Monitor CBC, LFT and urinalysis every 6 mth.
Adverse Reactions
Diarrhoea, epigastric pain, nausea, vomiting, intense yellow colouring of urine.
Overdose Reactions
Symptoms: diarrhoea. Management: symptomatic treatment.
Drug Interactions
Decreased absorption with aluminium and/or magnesium hydroxide antacids. Increased risk of diarrhoea with laxatives, antibiotics. Avoid co-admin with fibres and phytates.
See Below for More diacerein Drug Interactions
Mechanism of Actions
Diacerein is an anthraquinone derivative that has been used in osteoarthritis. It is thought to act via inhibition of interleukin-1β.
Administration
Should be taken with food. (Take w/ or immediately after meals.)
Storage Conditions
Oral: Store at 15-25°C.
ATC Classification
M01AX21 - diacerein ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products.
Storage
Oral: Store at 15-25°C.
Available As
  • Diacerein 100 mg
  • Diacerein 50 mg
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