Dexchlorpheniramine

Indications
 Oral
Allergic conditions
Adult: 2 mg every 4-6 hr.
Child: 2-5 yr: 0.5 mg; 6-12 yr: 1 mg, dose to be taken every 4-6 hr.
Max Dosage: Adult: 12 mg daily. Child 6-12 yrs: 6 mg daily; 2-5 yrs: 3 mg daily.
Contraindications
 Premature infants or full-term neonates.
Warnings / Precautions
 Pregnancy; lactation; severe CV disorders; asthma. May impair ability to drive or operate machinery. Angle-closure glaucoma, urinary retention, prostatic hypertrophy, pyloroduodenal obstruction; renal and hepatic impairment; elderly; epilepsy.
Adverse Reactions
 Exfoliative dermatitis. Sedation; antimuscarinic effects, CNS depression and disturbances; occasionally, paradoxical CNS stimulation; psychomotor impairment; headache; palpitations and arrhythmias; convulsions, sweating, myalgia, paraesthesias, extrapyramidal symptoms, tremor; sleep and GI disturbances. Rarely, hypersensitivity reactions and blood disorders; tinnitus, hypotension; hair loss. Injections may cause transient hypotension or CNS stimulation and irritation.
Drug Interactions
 CNS depressants eg, alcohol, barbiturates, hypnotics, opioid analgesics; anxiolytic sedatives and neuroleptics; other antimuscarinics; MAOIs; betahistine; ototoxic drugs.
See Below for More dexchlorpheniramine Drug Interactions
Lab Interactions
 May interfere with skin testing.
Mechanism of Actions
 Dexchlorpheniramine is the dextrorotatory isomer of chlorpheniramine and has approximately twice its activity by wt.
Administration
 May be taken with or without food.
ATC Classification
 R06AB02 - dexchlorpheniramine ; Belongs to the class of substituted alkylamines used as systemic antihistamines.
Available As
  • Dexchlorpheniramine Maleate 0.5 mg
  • Dexchlorpheniramine Maleate 2 mg
  • Dexchlorphexamine Maleate 2 mg
  • Dexchlorpheniramine 2 mg
  • Dexchlorpheniramine Maleate 6 mg
  • Dexchlorpheniramine 6 mg
  • Dexchlorphexamine Maleate 6 mg

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