Cyproheptadine

Indications
Oral
Allergic conditions
Adult: As HCl: 4 mg tid adjusted as necessary. Usual dose range: 12-16 mg daily in 3-4 divided doses. Up to 32 mg daily may be used in some cases.
Child: As HCl: 2-6 yr: 2 mg tid (max: 12 mg daily); 7-14 yr: 4 mg bid-tid (max: 16 mg daily).
Elderly:
Oral
Treatment and prophylaxis of migraine and other vascular headaches
Adult: As HCl: 4 mg, may repeat 30 minutes later. Not to exceed 8 mg within a 4-6-hr period. Maintenance dose: 4 mg every 4-6 hr.
Contraindications
Narrow-angle glaucoma; acute asthmatic attack; bladder neck obstruction; stenosing peptic ulcer; GIT obstruction; MAOIs therapy; hypersensitivity; neonates, lactation.
Warnings / Precautions
Elderly; epilepsy; tasks requiring mental alertness; symptomatic prostate hypertrophy; epilepsy; alcoholism; pregnancy.
Adverse Reactions
Slight to moderate drowsiness, fatigue; dry mouth, GI upsets, nausea; appetite increase, wt gain and impaired alertness.
Overdose Reactions
Symptoms may vary from CNS depression or stimulation to convulsions, respiratory and cardiac arrest and death, especially in infants and children. Atropine-like and GI symptoms may also occur. Treatment is supportive and symptomatic. Emesis or gastric lavage, followed by activated charcoal to reduce drug absorption. Saline cathartics may be useful as they dilute bowel content quickly by osmosis.
Drug Interactions
Masks ototoxicity produced by aminoglycosides and antibiotics.
Potentially Fatal: Potentiate CNS depressant actions of alcohol, barbiturates, sedatives, opioid analgesics and neuroleptics. Additive antimuscarinic action with MAOIs, atropine and tricyclic antidepressants.
See Below for More cyproheptadine Drug Interactions
Lab Interactions
Supression of diagnostic antigen skin test results and false-positive serum TCA screen.
Mechanism of Actions
Cyproheptadine is a sedating antihistamine with antimuscarinic, serotonin-antagonist and calcium-channel blocking properties. It competes for H1-receptor sites on effector cells in the GIT, blood vessels and resp tract. It is used as an appetite stimulant in some countries.
Absorption: Absorbed from the GIT (oral).
Metabolism: Completely hepatic.
Excretion: Via urine (as conjugates); via faeces.
Administration
May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.)
Storage Conditions
Oral: Store at 15-25°C.
ATC Classification
R06AX02 - cyproheptadine ; Belongs to the class of other antihistamines for systemic use.
Storage
Oral: Store at 15-25°C.
Available As
  • Cyproheptadine 0.5 mg
  • Cyproheptadine 1.5 mg
  • Cyproheptadine Hcl 1.5 mg
  • Cyproheptadine Hcl IP 1.5 mg
  • Cyproheptadine 2 mg
  • Cyproheptadine Hcl 2 mg
  • Cyproheptadine Hcl IP 2 mg
  • Cyproheptadine 4 mg
  • Cyproheptadine Hcl 4 mg
  • Cyproheptadine Hcl 5 mg
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