Copper

Indications
 Oral
Nutritional deficiency
Adult: As elemental copper. 900 mcg/day (max: 10 mg/day). Pregnant females 1 mg/day. Lactating females 1.3 mg/day. Adolescents ≥14 yr 890 mcg/day (max: 8 mg/day) .
Child: Birth-6 mth 200 mcg/day. 7-12 mth 220 mcg/day. 1-3 yr 340 mcg/day (max: 1 mg/day). 4-8 yr 440 mcg/day (max: 3 mg/day). 9-13 yr 700 mcg/day (max: 5 mg/day).
Intravenous
Nutritional deficiency
Adult: TPN 0.5-1.5 mg/day of elemental copper.
Child: TPN Full-term infants & childn 20 mcg elemental copper/kg/day IV. May be added to TPN.
Intravenous
Copper deficiency
Adult: 3 mg/day of elemental copper. May be added to TPN.
Child: Full-term infants & childn 20-30 mcg/kg/day IV of elemental copper. May be added to TPN.

Special Populations: Hepatic impairment: copper may accumulate if biliary obstruction or hepatic disease is present.
Warnings / Precautions
 Young children. Pregnancy, lactation. Wilson's disease. Chronic liver/renal failure. Hepatic impairment: copper may accumulate if biliary obstruction or hepatic disease is present.
Adverse Reactions
 Excessive dose may cause abdominal pain or cramps, diarrhoea, nausea/vomiting & metallic taste.
Overdose Reactions
 Severe GI effects. In extreme or long term overdosage, symptoms may be similar to that of Wilson's disease. Treatment is symptomatic and may involve the use of a chelating agent (e.g. penicillamine, trientine and zinc) to remove any absorbed metal. Dialysis may be useful.
Drug Interactions
 Ascorbic acid (large doses). Inhibit intestinal absorption by oral iron supplements, oral/parenteral Zn, D-Penicillamine or trientine chelate copper. Excessive amounts of molybdenum may produce copper deficiency.
See Below for More copper sulfate Drug Interactions
Food Interactions
 Concomitant intake with foods rich in phytic acid (unleavened bread, raw beans, seeds, nuts & grains & soy isolates) may decrease absorption of copper. Diets high in fructose may decrease copper status.
Mechanism of Actions
 An essential trace element important for proper functioning of many metalloenzymes including ceruloplasmin, ferroxidase II, lysyl oxidase, monoamine oxidase, Zn-copper superoxide dismutase, tyrosinase, dopamine-β-hydroxylase & cytochrome-c-oxidase. It is involved in erythropoiesis & leukopoiesis, bone mineralisation, elastin & collagen cross-linking, oxidative phosphorylation, catecholamine metabolism, melanin formation & antioxidant protection of cells. May also play a role in iron turnover, ascorbic acid metabolism, phospholipid metabolism, myelin formation, glucose homeostasis & cellular immune defense.
Absorption: Principally absorbed in the small intestine.
Excretion: 80% eliminated via the bile. Little excretion by the kidney.
ATC Classification
 V03AB20 - copper sulfate ; Belongs to the class of antidotes. Used in the management of phosphorus poisoning.
Available As
  • Copper –
  • Copper 0.01 mg
  • Copper 0.04 mg
  • Copper 0.05 mg
  • Copper 0.06 mg
  • Copper 0.1 mg
  • Copper 0.105 mg
  • Copper 0.11 mg
  • Copper 0.15 mg
  • Copper 0.2 mg
  • Copper 0.22 mg
  • Copper 0.25 mg
  • Copper 0.3 mg
  • Copper 0.35 mg
  • Copper 0.4 mg
  • Copper 0.45 mg
  • Copper 0.47 mg
  • Copper 0.5 mg
  • Copper 0.54 mg
  • Copper 0.6 mg
  • Copper 0.65 mg
  • Copper 0.67 mg
  • Copper 0.7 mg
  • Copper 0.70 mg
  • Copper 0.71 mg
  • Copper 0.75 mg
  • Copper 0.8 mg
  • Copper 0.9 mg
  • Copper 1 mcg
  • Copper 1 mg
  • Copper 1.0 mg
  • Copper 1.05 mg
  • Copper 1.1 mg
  • Copper 1.5 mcg
  • Copper 1.5 mg
  • Copper 1.77 mg
  • Copper 1.87 mg
  • Copper 10 mcg
  • Copper 100 mcg
  • Copper 10000 mcg
  • Copper 2 mg
  • Copper 2.2 mg
  • Copper 2.5 mg
  • Copper 20 mcg
  • Copper 20 mg
  • Copper 200 mg
  • Copper 220 mcg
  • Copper 25 mcg
  • Copper 250 mcg
  • Copper 250 mg
  • Copper 280 mcg
  • Copper 2mg
  • Copper 3 mg
  • Copper 3.0 mg
  • Copper 3.2 mg
  • Copper 3.92 mg
  • Copper 3.93 mg
  • Copper 300 mcg
  • Copper 3000 mcg
  • Copper 360 mcg
  • Copper 400 mcg
  • Copper 405 mcg
  • Copper 410 mcg
  • Copper 470 mcg
  • Copper 473 mcg
  • Copper 50 mcg
  • Copper 500 mcg
  • Copper 500 mg
  • Copper 630.5 mcg
  • Copper 75.65 mcg
  • Copper 750 mcg
  • Copper 8 mg

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