Cinnarizine

Indications
 Oral
Peripheral vascular disease
Adult: 75 mg bid or tid.
Elderly:
Oral
Motion sickness
Adult: 30 mg taken 2 hr before travel and 15 mg every 8 hr during the journey if necessary.
Child: 5-12 yr: 1/2 of adult dose.
Oral
Cerebrovascular disorders
Adult: 75 mg 1-3 times daily.
Oral
Vertigo and vestibular disorders
Adult: 30 mg tid.
Child: 5-12 yr: 1/2 of adult dose.
Contraindications
 Proven hypersensitivity to the drug. Parkinson's disease. Childn and neonates.
Warnings / Precautions
 Hypotension; pregnancy; lactation; elderly. May impair ability to drive or operate machineries.
Adverse Reactions
 Extrapyramidal symptoms sometimes associated with severe depression. Drowsiness, headache, GI upsets, unsteadiness, headache; rarely skin and hypersensitivity reactions, dry mouth, blurred vision, urinary difficulty or retention, constipation and increased gastric reflux, fatigue. Hypolipidaemic effect.
Drug Interactions
 CNS depressant effect enhanced with alcohol. Action potentiated by domperidone.
See Below for More cinnarizine Drug Interactions
Mechanism of Actions
 Cinnarizine has calcium-channel blocking activity selective for arterial smooth muscle. It also has some antihistamine activity. Cinnarizine acts as a labyrinthine sedative. It also improves microcirculation by reducing ischaemia-induced blood viscosity.
Absorption: Absorbed from the GIT (oral); peak plasma concentrations after 2-4 hrs.
Excretion: Via faeces (as unchanged drug), via urine (as metabolites); 3-6 hrs (elimination half-life).
Administration
 Should be taken with food.
ATC Classification
 N07CA02 - cinnarizine ; Belongs to the class of antivertigo preparations.
Available As
  • Cinnarizine 15 mg
  • Cinnarizine 20 mg
  • Cinnarizine 200 mg
  • Cinnarizine 25 mg
  • Cinnarizine 75 mg

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