Choline Salicylate

Indications
 Oral
Pain and fever
Adult: 435-870 mg every 4 hr when required.
Oral
Rheumatic disorders
Adult: 4.8-7.2 g daily in divided doses.
Buccal
Mouth lesions
Adult: Apply 8.7% gel on affected area.
Contraindications
 Haemophilia, haemorrhagic disorders, gout, history of hypersensitivity to salicylates. Severe renal or hepatic impairment; childn <12 yrs. Pregnancy and lactation.
Warnings / Precautions
 Peptic ulcers, errosive gastritis; asthma, allergic disorders; renal and hepatic impairment; dehydrated patients; uncontrolled hypertension; elderly.
Adverse Reactions
 GI disorders, fatigue, hypersensitivity reactions, skin eruptions, haemolytic anaemia, weakness, dyspnoea; local irritation (rectally); Reye's syndrome.
Potentially Fatal: Paroxysmal bronchospasm; hepatotoxicity; renal impairment; thrombocytopenia, iron-deficiency anaemia, occult bleeding, leukopenia; mild chronic salicylate intoxication.
Drug Interactions
 Increased toxicity of warfarin. Antacids may reduce salicylate effects. Increased risk of GI bleeding when used with corticosteroids.
See Below for More choline salicylate Drug Interactions
Lab Interactions
 Interfere with thyroid function test.
Mechanism of Actions
 Choline salicylate alleviates pain by inhibition of prostaglandin synthesis and reduce fever by acting on the hypothalamus heat-regulating center. It also blocks the generation of impulses.
Onset: 1-2 hr.
ATC Classification
 N02BA03 - choline salicylate ; Belongs to the class of salicylic acids and derivatives agents. Used to relieve pain and fever.
Available As
  • Choline Salicylate 8% w/v
  • Choline Salicylate 8.7%
  • Choline Salicylate 8.7% w/v
  • Choline Salicylate 8.7% w/w
  • Choline Salicylate 8.70% w/w
  • Choline Salicylate 9%
  • Choline Salicylate 9% w/v

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