Chlorzoxazone

Indications
 Oral
Painful muscle spasm associated with musculoskeletal conditions
Adult: Initially, 500 mg 3-4 times daily, may subsequently reduce to 250 mg 3-4 times daily. Max: 750 mg 3-4 times daily.
Contraindications
 Hypersensitivity. Liver disease. Porphyria. Lactation.
Warnings / Precautions
 Pregnancy, known allergies. Tasks requiring mental alertness may be impaired. Monitor liver function.
Adverse Reactions
 Drowsiness, dizziness, lightheadedness, headache, excitement, restlessness, GI disturbances, irritability, sensitivity reactions (skin rash). Jaundice, liver damage reported. Orange or reddish-purple urine.
Potentially Fatal: Anaphylactoid reactions, angioedema, fatal hepatocellular toxicity.
Drug Interactions
 Potentially Fatal: Additive effect when used with other CNS depressants or alcohol.
See Below for More chlorzoxazone Drug Interactions
Food Interactions
 Additive CNS effects when taken with alcohol.
Mechanism of Actions
 Chlorzoxazone acts at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic areas involved in producing and maintaining skeletal muscle spasm of varied etiology, thus relieving painful musculoskeletal conditions. It also has sedative property.
Onset: 1 hr.
Duration: 3-4 hr.
Absorption: Completely absorbed from the GI tract (oral); peak plasma concentrations after 1-2 hr.
Metabolism: Hepatic; yielding 6-hydroxychlorzoxazone.
Excretion: Via urine (mainly as glucuronide); 1 hr (elimination half-life).
Administration
 Should be taken with food.
Storage Conditions
 Oral: Store at 15-30°C.
ATC Classification
 M03BB03 - chlorzoxazone ; Belongs to the class of oxazol, thiazine, and triazine derivative agents. Used as centrally-acting muscle relaxants.
Storage
 Oral: Store at 15-30°C.
Available As
  • Chlorzoxazone 100 mg
  • Chlorzoxazone 15 mg
  • Chlorzoxazone 200 mg
  • Chlorzoxazone 250 mg
  • Chlorzoxazone 325 mg
  • Chlorzoxazone 375 mg
  • Chlorzoxazone 50 mg
  • Chlorzoxazone 500 mg

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