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Chlorpheniramine indications, dose, side effects & concise monograph

Chlorpheniramine

Indications
 Oral
Allergic conditions
Adult: 4 mg every 4-6 hr. Max: 24 mg daily.
Child: 1-2 yr: 1 mg bid, 2-5 yr: 1 mg every 4-6 hr, 6-12 yr: 2 mg every 4-6 hr. Max: 6 mg daily (1-5 yr); 12 mg daily (6-12 yr).
Parenteral
Adjunct in the emergency treatment of anaphylactic shock
Adult: 10-20 mg IM, SC, or slow IV inj over 1 min. Max dose: 40 mg daily.
Child: 87.5 mcg/kg SC 4 times daily

Incompatibility: Incompatible with calcium chloride, kanamycin sulfate, noradrenaline acid tartrate, pentobarbital sodium and meglumine adipiodone.
Incompatibility: Incompatible with calcium chloride, kanamycin sulfate, noradrenaline acid tartrate, pentobarbital sodium and meglumine adipiodone.
Contraindications
 Hypersensitivity, neonates.
Warnings / Precautions
 Elderly, pylori duodenal obstruction, angle-closure glaucoma, urinary retention, prostatic hyperplasia, epilepsy, renal and hepatic impairment. May affect performance of skilled tasks. BPH, bladder neck obstruction, hypertension. Pregnancy, lactation.
Adverse Reactions
 CNS depression, sedation, drowsiness, lassitude, dizziness. GI upsets, anorexia, or increased appetite, epigastric pain, blurring of vision, dysuria, dryness of mouth, tightness in chest, hypotension, muscular weakness, tinnitus, euphoria, headache, paradoxical CNS stimulation.
Potentially Fatal: CV collapse and respiratory failure.
Drug Interactions
 Potentiates sedative effect of psychotropic drugs e.g. barbiturates, hypnotics, opioid analgesics, anxiolytics and antipsychotics. Interaction with alcohol could be dangerous (sedation/excitation).
See Below for More chlorphenamine Drug Interactions
Food Interactions
 Reduced bioavailability
Mechanism of Actions
 Chlorphenamine is an H1-receptor antagonist which competetively blocks H1-receptor sites on tissues.
Duration: 4-6 hr.
Absorption: Absorbed relatively slowly from the GI tract (oral); peak plasma concentrations after 2.5-6 hr.
Distribution: Widely distributed; CNS. Protein-binding: 70%.
Metabolism: Extensive; converted to desmethyl- and didesmethylchlorphenamine.
Excretion: Via urine (as unchanged drug and metabolites).
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store below 25°C. Parenteral: Store below 25°C.
ATC Classification
 R06AB04 - chlorphenamine ; Belongs to the class of substituted alkylamines used as systemic antihistamines.
Storage
 Oral: Store below 25°C. Parenteral: Store below 25°C.
Available As
  • Chlorpheniramine Maleate 0.01%
  • Chlorpheniramine Maleate 0.01% w/v
  • Chlorpheniramine Maleate 0.02% w/v
  • Chlorpheniramine Maleate 0.03% w/v
  • Chlorpheniramine Maleate 0.1 mg
  • Chlorpheniramine Maleate 0.1%
  • Chlorpheniramine Maleate 0.1% w/v
  • Chlorpheniramine Maleate 0.2 % w/v
  • Chlorpheniramine 0.2%
  • Chlorpheniramine Maleate 0.2% w/v
  • Chlorpheniramine Maleate 0.2% w/w
  • Chlorpheniramine Maleate 0.4% w/v
  • Chlorpheniramine Maleate 0.5 mg
  • Chlorpheniramine Maleate 1 mg
  • Chlorpheniramine 1 mg
  • Chlorpheniramine 1.25 mg
  • Chlorpheniramine Maleate 1.25 mg
  • Chlorpheniramine Maleate 1.5 mg
  • Chlorpheniramine Maleate 10 mg
  • Chlorpheniramine 10 mg
  • Chlorpheniramine 100 mg
  • Chlorpheniramine Maleate 100 mg
  • Chlorpheniramine Maleate 15 mg
  • Chlorpheniramine Maleate 2 mg
  • Chlorpheniramine 2 mg
  • Chlorpheniramine Maleate 2 mg, 4 mg
  • Chlorpheniramine Maleate 2.0 mg
  • Chlorpheniramine 2.5 mg
  • Chlorpheniramine Maleate 2.5 mg
  • Chlorpheniramine Maleate 2.54 mg
  • Chlorpheniramine Maleate 20 mg
  • Chlorpheniramine Maleate 2mg
  • Chlorpheniramine 3 mg
  • Chlorpheniramine Maleate 3 mg
  • Chlorpheniramine 4 mg
  • Chlorpheniramine Maleate 4 mg
  • Chlorpheniramine Maleate 4. 5 mg
  • Chlorpheniramine Maleate 4.0 mg
  • Chlorpheniramine Maleate 4mg
  • Chlorpheniramine Maleate 5 mg
  • Chlorpheniramine Maleate 6 mg
  • Chlorpheniramine Maleate 8 mg
  • Chlorpheniramine 8 mg

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    One Response to Chlorpheniramine

    1. August 27, 2013 at 3:56 pm #

      I hav developed chest pain after taking tab Chlorpheniramine(piriton). I want to know whether it will resolve or not. 13-hrs have passed but the pain persists.

      Reply

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