Indications |
Oral Allergic conditions Adult: 4 mg every 4-6 hr. Max: 24 mg daily. Child: 1-2 yr: 1 mg bid, 2-5 yr: 1 mg every 4-6 hr, 6-12 yr: 2 mg every 4-6 hr. Max: 6 mg daily (1-5 yr); 12 mg daily (6-12 yr). Parenteral Adjunct in the emergency treatment of anaphylactic shock Adult: 10-20 mg IM, SC, or slow IV inj over 1 min. Max dose: 40 mg daily. Child: 87.5 mcg/kg SC 4 times daily Incompatibility: Incompatible with calcium chloride, kanamycin sulfate, noradrenaline acid tartrate, pentobarbital sodium and meglumine adipiodone. Incompatibility: Incompatible with calcium chloride, kanamycin sulfate, noradrenaline acid tartrate, pentobarbital sodium and meglumine adipiodone. |
Contraindications |
Hypersensitivity, neonates. |
Warnings / Precautions |
Elderly, pylori duodenal obstruction, angle-closure glaucoma, urinary retention, prostatic hyperplasia, epilepsy, renal and hepatic impairment. May affect performance of skilled tasks. BPH, bladder neck obstruction, hypertension. Pregnancy, lactation. |
Adverse Reactions |
CNS depression, sedation, drowsiness, lassitude, dizziness. GI upsets, anorexia, or increased appetite, epigastric pain, blurring of vision, dysuria, dryness of mouth, tightness in chest, hypotension, muscular weakness, tinnitus, euphoria, headache, paradoxical CNS stimulation. Potentially Fatal: CV collapse and respiratory failure. |
Drug Interactions |
Potentiates sedative effect of psychotropic drugs e.g. barbiturates, hypnotics, opioid analgesics, anxiolytics and antipsychotics. Interaction with alcohol could be dangerous (sedation/excitation). See Below for More chlorphenamine Drug Interactions |
Food Interactions |
Reduced bioavailability |
Mechanism of Actions |
Chlorphenamine is an H1-receptor antagonist which competetively blocks H1-receptor sites on tissues. Duration: 4-6 hr. Absorption: Absorbed relatively slowly from the GI tract (oral); peak plasma concentrations after 2.5-6 hr. Distribution: Widely distributed; CNS. Protein-binding: 70%. Metabolism: Extensive; converted to desmethyl- and didesmethylchlorphenamine. Excretion: Via urine (as unchanged drug and metabolites). |
Administration |
May be taken with or without food. |
Storage Conditions |
Oral: Store below 25°C. Parenteral: Store below 25°C. |
ATC Classification |
R06AB04 - chlorphenamine ; Belongs to the class of substituted alkylamines used as systemic antihistamines. |
Storage |
Oral: Store below 25°C. Parenteral: Store below 25°C. |
Available As |
|
Chlorpheniramine
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One Response to Chlorpheniramine
Post Review about Chlorpheniramine
Chlorpheniramine Containing Brands
to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.Chlorpheniramine is used in following diseases
Drug - Drug Interactions of Chlorpheniramine
I hav developed chest pain after taking tab Chlorpheniramine(piriton). I want to know whether it will resolve or not. 13-hrs have passed but the pain persists.