Cefdinir

Indications
 Oral
Susceptible infections
Adult: 600 mg once daily as a single or in 2 divided doses.
Child: 14 mg/kg daily. Max: 600 mg daily.
CrCl (ml/min)Dosage Recommendation
<30300 mg once daily.


Special Populations: Renal impairment: If CrCl is <30 mL/min, dose is 300 mg once daily.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Penicillin-sensitive patients; superinfection; seizure; pseudomembranous colitis; pregnancy, lactation; renal or hepatic insufficiency.
Adverse Reactions
 Headache, dizziness, fever; nausea, vomiting, diarrhoea, abdominal pain; rash; leukopaenia, thrombocytopaenia, haemolytic anaemia.
Potentially Fatal: Anaphylaxis; renal and hepatic failure.
Drug Interactions
 Concomitant admin with antacids and Fe reduce the rate and extent of absorption. Probenecid reduces renal elimination. Antacids reduce rate and extent of absorption.
See Below for More cefdinir Drug Interactions
Lab Interactions
 Administration with Fe supplements may color the urine red.
Mechanism of Actions
 Cefdinir binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption: Absorbed from the GIT (oral); peak plasma concentrations after 2-4 hrs.
Distribution: Widely into body tissues. Protein-binding: 60-70%
Metabolism: Minimal metabolism.
Excretion: Via the urine; 1.7 hrs (elimination half-life). Removed by dialysis.
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store at 25°C.
ATC Classification
 J01DD15 - cefdinir ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Storage
 Oral: Store at 25°C.
Available As
  • Cefdinir 100 mg
  • Cefdinir 1000 mg
  • Cefdinir 125 mg
  • Cefdinir 150 mg
  • Cefdinir 300 mg
  • Cefdinir 500 mg

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