Indications |
Oral Prophylaxis of myocardial infarction Adult: 75-325 mg once daily. Lower doses should be used in patients receiving ACE inhibitors. Oral Stent implantation Adult: 325 mg 2 hr before procedure followed by 160-325 mg/day thereafter. Oral Juvenile rheumatoid arthritis Child: 80-100 mg/kg daily in 5 or 6 divided doses. Up to 130 mg/kg daily in acute exacerbations if necessary. Oral Mild to moderate pain and fever Adult: 325-650 mg repeated every 4-6 hr according to response. Max: 4 g/day. May also be given rectally. Max Dosage: Oral Pain and inflammation associated with musculoskeletal and joint disorders Adult: Initial: 2.4-3.6 g/day in divided doses. Usual maintenance: 3.6-5.4 g/day. Monitor serum concentrations. |
Contraindications |
Hypersensitivity (attacks of asthma, angioedema, urticaria or rhinitis), active peptic ulceration; pregnancy (3rd trimester), children <12 yr, patients with haemophilia or haemorrhagic disorders, gout, severe renal or hepatic impairment, lactation. |
Warnings / Precautions |
History of peptic ulcer or those prone to dyspepsia and those with gastric mucosal lesion, asthma or allergic disorders, dehydrated patients, uncontrolled hypertension, impaired renal or hepatic function, elderly. |
Adverse Reactions |
GI disturbances; prolonged bleeding time, rhinitis, urticaria and epigastric discomfort; angioedema, salicylism, tinnitus; bronchospasm. Potentially Fatal: Gastric erosion, ulceration and bleeding; severe, occasionally fatal exacerbation of airway obstruction in asthma; Reye's syndrome (children <12 yr). Hepatotoxicity; CNS depression which may lead to coma; CV collapse and resp failure; paroxysmal bronchospasm and dyspnoea. |
Overdose Reactions |
Symptoms may include hyperventilation, fever, restlessness, ketosis, and respiratory alkalosis and metabolic acidosis. CNS depression may lead to coma; CV collapse and respiratory failure. In children, drowsiness and metabolic acidosis commonly occur; hypoglycaemia may be severe. |
Drug Interactions |
Alcohol, corticosteroids, analgin, phenylbutazone and oxyphenbutazone may increase risk of GI ulceration. Aspirin increases phenytoin levels. May antagonize actions of uricosurics and spironolactone. Potentially Fatal: May potentiate effects of anticoagulants, methotrexate and oral hypoglycaemics. See Below for More aspirin Drug Interactions |
Lab Interactions |
Interferes with thyroid function tests. |
Food Interactions |
Vitamin-rich foods increase urinary excretion. |
Mechanism of Actions |
Aspirin is an analgesic, anti-inflammatory and antipyretic. It inhibits cyclooxygenase, which is responsible for the synthesis of prostaglandin and thromboxane. It also inhibits platelet aggregation. Duration: 4-6 hr. Absorption: Rapidly absorbed from the GI tract (oral); less reliable (rectal); absorbed through the skin (topical). Peak plasma concentrations after 1-2 hr. Distribution: Widely distributed; crosses the placenta; enters breast milk. Protein-binding: 80-90%. Metabolism: Hepatic; converted to metabolites. Excretion: Via urine by glomerular filtration, active renal tubular secretion and passive tubular reabsorption (as unchanged drug); via haemodialysis; 15-20 minutes (elimination half-life, parent drug). |
Administration |
Should be taken with food. |
Available As |
|
Aspirin
Post Review about Aspirin Click here to cancel reply.
Aspirin Containing Brands
Aspirin is used in following diseases
Drug - Drug Interactions of Aspirin
Latest News
- FDA approves Ruconest for treatment of hereditary angioedema
- FDA recommend against aspirin to prevent First Heart Attacks
- FDA approves Pomalyst (pomalidomide) for advanced multiple myeloma
- FDA approves three new drug treatments for type 2 diabetes
- Long-term consequences of vaginal delivery on the pelvic floor
No comments yet.