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Aspirin indications, dose, side effects & concise monograph


Prophylaxis of myocardial infarction
Adult: 75-325 mg once daily. Lower doses should be used in patients receiving ACE inhibitors.
Stent implantation
Adult: 325 mg 2 hr before procedure followed by 160-325 mg/day thereafter.
Juvenile rheumatoid arthritis
Child: 80-100 mg/kg daily in 5 or 6 divided doses. Up to 130 mg/kg daily in acute exacerbations if necessary.
Mild to moderate pain and fever
Adult: 325-650 mg repeated every 4-6 hr according to response. Max: 4 g/day. May also be given rectally.
Max Dosage:
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: Initial: 2.4-3.6 g/day in divided doses. Usual maintenance: 3.6-5.4 g/day. Monitor serum concentrations.
Hypersensitivity (attacks of asthma, angioedema, urticaria or rhinitis), active peptic ulceration; pregnancy (3rd trimester), children <12 yr, patients with haemophilia or haemorrhagic disorders, gout, severe renal or hepatic impairment, lactation.
Warnings / Precautions
History of peptic ulcer or those prone to dyspepsia and those with gastric mucosal lesion, asthma or allergic disorders, dehydrated patients, uncontrolled hypertension, impaired renal or hepatic function, elderly.
Adverse Reactions
GI disturbances; prolonged bleeding time, rhinitis, urticaria and epigastric discomfort; angioedema, salicylism, tinnitus; bronchospasm.
Potentially Fatal: Gastric erosion, ulceration and bleeding; severe, occasionally fatal exacerbation of airway obstruction in asthma; Reye's syndrome (children <12 yr). Hepatotoxicity; CNS depression which may lead to coma; CV collapse and resp failure; paroxysmal bronchospasm and dyspnoea.
Overdose Reactions
Symptoms may include hyperventilation, fever, restlessness, ketosis, and respiratory alkalosis and metabolic acidosis. CNS depression may lead to coma; CV collapse and respiratory failure. In children, drowsiness and metabolic acidosis commonly occur; hypoglycaemia may be severe.
Drug Interactions
Alcohol, corticosteroids, analgin, phenylbutazone and oxyphenbutazone may increase risk of GI ulceration. Aspirin increases phenytoin levels. May antagonize actions of uricosurics and spironolactone.
Potentially Fatal: May potentiate effects of anticoagulants, methotrexate and oral hypoglycaemics.
See Below for More aspirin Drug Interactions
Lab Interactions
Interferes with thyroid function tests.
Food Interactions
Vitamin-rich foods increase urinary excretion.
Mechanism of Actions
Aspirin is an analgesic, anti-inflammatory and antipyretic. It inhibits cyclooxygenase, which is responsible for the synthesis of prostaglandin and thromboxane. It also inhibits platelet aggregation.
Duration: 4-6 hr.
Absorption: Rapidly absorbed from the GI tract (oral); less reliable (rectal); absorbed through the skin (topical). Peak plasma concentrations after 1-2 hr.
Distribution: Widely distributed; crosses the placenta; enters breast milk. Protein-binding: 80-90%.
Metabolism: Hepatic; converted to metabolites.
Excretion: Via urine by glomerular filtration, active renal tubular secretion and passive tubular reabsorption (as unchanged drug); via haemodialysis; 15-20 minutes (elimination half-life, parent drug).
Should be taken with food.
Available As
  • Aspirin 100 mg
  • Aspirin 150 mg
  • Aspirin 162.5 mg
  • Aspirin 200 mg
  • Aspirin 25 mg
  • Aspirin 250 mg
  • Aspirin 300 mg
  • Aspirin 325 mg
  • Aspirin 350 mg
  • Aspirin 40 mg
  • Aspirin 400 mg
  • Aspirin 50 mg
  • Aspirin 500 mg
  • Aspirin 60 mg
  • Aspirin 75 mg
  • Aspirin 80 mg
  • Aspirin 81 mg
  • Aspirin 82 mg
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