Indications |
Oral Acute uncomplicated falciparum malaria Adult: 80 mg daily, to be taken with lumefantrine 480 mg daily. Doses to be taken at diagnosis and repeated after 8, 24, 36, 48 and 60 hr. Total doses: 6. Child: Daily doses based on body wt: 5-14 kg: 20 mg with lumefantrine 120 mg; 15-24 kg: 40 mg with lumefantrine 240 mg; 25-34 kg: 60 mg with lumefantrine 360 mg and >34 kg: 80 mg with lumefantrine 480 mg. Doses to be taken at diagnosis and repeated after 8, 24, 36, 48 and 60 hr. Total doses: 6. |
Contraindications |
Hypersensitivity. |
Warnings / Precautions |
Pregnancy and lactation. Avoid concomitant use of drugs known to prolong QT interval or monitor such patients. |
Adverse Reactions |
Mild GI disturbance, dizziness, tinnitus, reduction in reticulocyte and leucocyte counts, nausea, vomiting, abdominal pain, bradycardia, 1st-degree heart block, transient increase in serum transaminases. |
Drug Interactions |
Artemether causes QT prolongation in some patients. Thus concomitant use of erythromycin, terfenadine, procainamide, quinidine, disopyramide, amiodarone, bretylium, bepridil, sotalol, astemizole, probucol, tricyclic antidepressants, phenothiazines may be avoided. See Below for More artemether Drug Interactions |
Mechanism of Actions |
Artemether is a potent and rapidly acting blood schizontocide, which is highly efficacious in treating chloroquine-resistant falciparum malaria, and complicated falciparum malaria including cerebral malaria. Its quick onset of effect and high efficacy in bringing down the parasite load are the properties which make this drug a suitable therapeutic option against falciparum infection. Metabolism: Rapidly hydrolysed to the active metabolite dihydroartemisinin. Excretion: Elimination half-life: about 4-11 hr after IM or oral admin. |
Administration |
Should be taken with food. |
Storage Conditions |
Oral: Store below 30°C. |
ATC Classification |
P01BE02 - artemether ; Belongs to the class of artemisinin and derivative antimalarials. |
Storage |
Oral: Store below 30°C. |
Available As |
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Artemether
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Artemether Containing Brands
Artemether is used in following diseases
Drug - Drug Interactions of Artemether
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