Aripiprazole

Indications
 Oral
Schizophrenia
Adult: Initial dose: 10-15 mg once daily. Usual maintenance dose: 15 mg once daily. Adjust dose at intervals of at least 2 wk. Max dose: 30 mg once daily.
Oral
Acute manic episodes of bipolar disorder
Adult: 30 mg once daily, decreased to 15 mg once daily based on tolerability.
Contraindications
 Hypersensitivity. Lactation. Children <18 yr.
Warnings / Precautions
 Patients with known CV diseases (e.g. history of MI, IHD, CCF or conduction abnormalities), cerebrovascular diseases or conditions which would predispose patients to hypotension; Alzheimer's disease and dementia. Caution when operating hazardous machinery, including automobiles when taking aripiprazole. Pregnancy.
Adverse Reactions
 Headache, agitation, insomnia, somnolence; dyspepsia, constipation, pain, nausea, vomiting; asthaenia, dizziness, abdominal pain; dry mouth; anxiety, akathisia; orthostatic hypotension; hypertonia, tremor and blurred vision.
Overdose Reactions
 Symptoms include nausea, vomiting, asthenia, diarrhoea and somnolence.
Drug Interactions
 Drugs that induce CYP3A4 (e.g. carbamazepine) could cause an increase in aripiprazole clearance and lower blood levels. Inhibitors of CYP3A4 (e.g. ketoconazole) or CYP2D6 (e.g. quinidine, fluoxetine or paroxetine) can inhibit aripiprazole elimination and cause increased blood levels. Increased CNS depression with ethanol.
See Below for More aripiprazole Drug Interactions
Food Interactions
 Ingestion with a high-fat meal delays time to peak plasma level.
Mechanism of Actions
 Aripiprazole acts as a partial agonist at D2 and 5-HT1A receptors and as an antagonist at 5-HT2A receptors.
Absorption: Well absorbed from the GI tract. Absolute bioavailability: about 87%.
Distribution: Protein binding: about 99%.
Metabolism: Mainly in the liver and the pathways involved include dehydrogenation and hydroxylation.
Excretion: About 55% excreted in faeces and 25% in urine, mainly in the form of metabolites.
Administration
 May be taken with or without food.
ATC Classification
 N05AX12 - aripiprazole ; Belongs to the class of other antipsychotics.
Available As
  • Aripiprazole 10 mg
  • Aripiprazole 15 mg
  • Aripiprazole 20 mg
  • Aripiprazole 30 mg
  • Aripiprazole 5 mg

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