Adapalene

Indications
Topical/Cutaneous
Acne
Adult: As 0.1% solution/cream/gel: Apply thinly onto affected areas once daily at night after cleansing.
Contraindications
Hypersensitivity.
Warnings / Precautions
Patients with sunburn, eczema. Pregnancy, lactation. Avoid excessive exposure to sunlight or UV irradiation. Keep away from the eyes, lips, nostrils and mucous membranes. Do not apply to cuts, abrasions, scaly or flaky skin, or patches of sunburned skin. Use with caution with preparations containing sulfur, resorcinol, or salicylic acid.
Adverse Reactions
Mild skin irritation, scaling, erythema, cutaneous dryness, sensations of stinging and burning, pruritus.
Drug Interactions
Increased irritation may occur with medicated or abrasive soaps, products with a pronounced drying effect and those containing alcohol or astringents.
See Below for More adapalene Drug Interactions
Mechanism of Actions
Adapalene binds to specific retinoic acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.
Absorption: Minimal (topical).
Excretion: Bile.
Storage Conditions
Topical/Cutaneous: Store below 25°C.
ATC Classification
D10AD03 - adapalene ; Belongs to the class of topical retinoid preparations used in the treatment of acne.
Storage
Topical/Cutaneous: Store below 25°C.
Available As
  • Adapalene 0.1%
  • Adapalene 0.1% w/v
  • Adapalene 0.1% w/w
  • Adapalene 1 mg
  • Adapalene 1%
  • Adapalene 2% w/w
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