Duloxetine vs Iobenguane

Interacting Drugs
Duloxetine
vs
Iobenguane (metaiodobenzylguanidine ,mIBG, MIBG)
Security Level
Major, Avoid combination
Interaction Effect

Serotonin/Norepinephrine Reuptake Inhibitors may diminish the therapeutic effect ( or diagnostic efficacy ) of Iobenguane I 123.

Mechanism

Iobenguane is structurally similar to norepinephrine and therefore is taken up and stored in adrenergic tissue such as adrenal medulla, heart, liver, lungs, salivary glands, and spleen. Iobenguane is bound to radioactive iodine in order to obtain organ and tissue images.Serotonin/Norepinephrine Reuptake Inhibitors may block this mechanism.

Management

Avoid combination.


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