Codeine vs Duloxetine

Interacting Drugs
Codeine
vs
Duloxetine
Security Level
Minor, Monitor Therapy
Interaction Effect

Duloxetine may diminish the therapeutic effect of Codeine.

Mechanism

CYP2D6 Inhibitors (Moderate) may diminish the therapeutic effect of Codeine. These CYP2D6 inhibitors may prevent the metabolic conversion of codeine to its active metabolite morphine.

Management

Monitor therapy


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