Tinzaparin vs Drotrecogin Alfa

Interacting Drugs
Tinzaparin
vs
Drotrecogin Alfa
Security Level
Moderate, Consider therapy modification
Mechanism
Drotrecogin Alfa: Heparin (Low Molecular Weight) may enhance the adverse/toxic effect of Drotrecogin Alfa. Bleeding may occur.
Management
Potential benefits of therapeutic doses of LMW heparins should be weighed against an increased risk of bleeding in patients who receive drotrecogin alfa. In patients receiving prophylactic LMW heparin doses consider continuing this during drotrecogin.

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