Tadalafil vs Ritonavir

Interacting Drugs
Tadalafil
vs
Ritonavir
Security Level
Moderate, Consider therapy modification
Mechanism
Ritonavir: May increase the serum concentration of Tadalafil.
Management
Erectile dysfunction: tadalafil max = 2.5 mg/day (daily use) or 10 mg/72 hrs (as needed use). Pulmonary arterial hypertension: use initial dose of 20 mg/day; increase to 40 mg/day as tolerated (adult doses). Avoid during ritonavir initiation.

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