Tadalafil vs CYP3A4 Inhibitors (Strong)

Interacting Drugs
Tadalafil
vs
CYP3A4 Inhibitors (Strong)
Security Level
Moderate, Consider therapy modification
Mechanism
CYP3A4 Inhibitors (Strong): May increase the serum concentration of Tadalafil.
Management
Erectile dysfunction: tadalafil max = 2.5 mg/day (daily use) or 10 mg/72 hrs (as needed use) (adult doses). Avoid use of tadalafil with a strong CYP3A4 inhibitor for treatment of pulmonary arterial hypertension. Exceptions: Ritonavir.

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