Tadalafil vs CYP3A4 Inducers (Strong)

Interacting Drugs
Tadalafil
vs
CYP3A4 Inducers (Strong)
Security Level
Moderate, Consider therapy modification
Mechanism
CYP3A4 Inducers (Strong): May decrease the serum concentration of Tadalafil.
Management
Erectile dysfunction: monitor for decreased effectiveness - no standard dose adjustments recommended. Avoid use of tadalafil for pulmonary arterial hypertension in patients receiving a strong CYP3A4 inducer.

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