Rifabutin vs Imatinib

Interacting Drugs
Rifabutin
vs
Imatinib
Security Level
Moderate, Consider therapy modification
Mechanism
Imatinib: Rifamycin Derivatives may decrease the serum concentration of Imatinib.
Management
Avoid concurrent use of imatinib with the rifamycin derivatives when possible. If such a combination must be used, increase imatinib dose by at least 50% and monitor the patient's clinical response closely.

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