Quinidine vs Rifamycin Derivatives

Interacting Drugs
Quinidine
vs
Rifamycin Derivatives
Security Level
Moderate, Consider therapy modification
Mechanism
Rifamycin Derivatives: May decrease the serum concentration of QuiNIDine.
Management
Consider alternatives to combination treatment with quinidine and rifampin due to large potential decreases in quinidine concentrations. Monitor for decreased quinidine concentrations/effects with initiation/dose increase of any rifamycin derivative.

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