Quinidine vs Pazopanib

Interacting Drugs
Quinidine
vs
Pazopanib
Security Level
Moderate, Consider therapy modification
Mechanism
Pazopanib: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Pazopanib.
Management
Avoid concurrent use of pazopanib with strong inhibitors of CYP3A4 whenever possible. If it is not possible to avoid such a combination, reduce pazopanib adult dose to 400 mg. Further dose reductions may also be required.

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