Promethazine, phenylephrine, and codeine vs CYP2D6 Inhibitors (Moderate)

Interacting Drugs
Promethazine, phenylephrine, and codeine
vs
CYP2D6 Inhibitors (Moderate)
Security Level
Minor, Monitor Therapy
Mechanism
CYP2D6 Inhibitors (Moderate): May diminish the therapeutic effect of Codeine. These CYP2D6 inhibitors may prevent the metabolic conversion of codeine to its active metabolite morphine.
Management
Monitor therapy

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