Pregabalin vs Methotrimeprazine

Interacting Drugs
Pregabalin
vs
Methotrimeprazine
Security Level
Moderate, Consider therapy modification
Mechanism
Methotrimeprazine: CNS Depressants may enhance the CNS depressant effect of Methotrimeprazine. Methotrimeprazine may enhance the CNS depressant effect of CNS Depressants.
Management
Reduce adult dose of CNS depressant agents by 50% with initiation of concomitant methotrimeprazine therapy. Further CNS depressant dosage adjustments should be initiated only after clinically effective methotrimeprazine dose is established.

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