Polysaccharide-iron complex, vitamin B12, and folic acid vs Cefdinir

Interacting Drugs
Polysaccharide-iron complex, vitamin B12, and folic acid
vs
Cefdinir
Security Level
Moderate, Consider therapy modification
Mechanism
Cefdinir: Iron Salts may decrease the serum concentration of Cefdinir. Red-appearing, non-bloody stools may also develop due to the formation of an insoluble iron-cefdinir complex.
Management
Avoid concurrent cefdinir and oral iron when possible. Separating doses by several hours may minimize interaction. Iron-containing infant formulas do not appear to interact with cefdinir.

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