Pentazocine and acetaminophen vs Analgesics (Opioid)

Interacting Drugs
Pentazocine and acetaminophen
vs
Analgesics (Opioid)
Security Level
Moderate, Consider therapy modification
Mechanism
Analgesics (Opioid): Mixed Agonist / Antagonist Opioids may diminish the analgesic effect of Analgesics (Opioid).
Management
Seek alternatives to mixed agonist/antagonist opioids in patients receiving pure opioid agonists, and monitor for symptoms of therapeutic failure/high dose requirements (or withdrawal in opioid-dependent patients) if patients receive these combinations.

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Other Interactions of Analgesics (Opioid)

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