Methylprednisolone vs CYP3A4 Inhibitors (Strong)

Interacting Drugs
Methylprednisolone
vs
CYP3A4 Inhibitors (Strong)
Security Level
Moderate, Consider therapy modification
Mechanism
CYP3A4 Inhibitors (Strong): May increase the serum concentration of MethylPREDNISolone.
Management
Consider methylprednisolone dose titration and/or adjustments in patients receiving strong CYP3A4 inhibitors (eg, azole antifungals, protease inhibitors) and monitor for increased steroid related adverse effects.

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