Lovastatin vs Protease Inhibitors

Interacting Drugs
Lovastatin
vs
Protease Inhibitors
Security Level
Moderate, Consider therapy modification
Mechanism
Protease Inhibitors: May increase the serum concentration of HMG-CoA Reductase Inhibitors. Limited data suggest pravastatin may slightly decrease protease inhibitor concentrations.
Management
Lovastatin and simvastatin are contraindicated with protease inhibitors; also, avoid rosuvastatin with indinavir. Use lowest possible HMG-CoA reductase inhibitor dose and monitor for signs of toxicity if these agents are used concomitantly.

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Lovastatin vs Protease Inhibitors

Interacting Drugs
Lovastatin
vs
Protease Inhibitors
Security Level
Major, Avoid combination
Mechanism
Protease Inhibitors: May increase the serum concentration of Lovastatin.
Management
Avoid combination

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