Lovastatin vs Niacin

Interacting Drugs
Lovastatin
vs
Niacin
Security Level
Moderate, Consider therapy modification
Mechanism
Niacin: May enhance the adverse/toxic effect of HMG-CoA Reductase Inhibitors.
Management
This is of greatest concern with niacin doses of 1 g or greater daily. Avoid simvastatin 80 mg in combination with niacin 1 g or greater in Chinese patients. Canadian labeling contraindicates use of niacin with rosuvastatin 40 mg.

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