Lovastatin vs Macrolide Antibiotics

Interacting Drugs
Lovastatin
vs
Macrolide Antibiotics
Security Level
Moderate, Consider therapy modification
Mechanism
Macrolide Antibiotics: May decrease the metabolism of HMG-CoA Reductase Inhibitors.
Management
Avoid lovastatin or simvastatin with erythro-, clarithro-, or telithromycin. Limit pitavastatin to a 1 mg/day maximum adult dose with erythromycin. Atorvastatin dose adjustments may be required. Increase monitoring for toxicity with any such combination. Exceptions: Azithromycin; Azithromycin (Systemic); Fidaxomicin (Systemic); Spiramycin.

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