Lovastatin vs Grapefruit Juice

Interacting Drugs
Lovastatin
vs
Grapefruit Juice
Security Level
Moderate, Consider therapy modification
Mechanism
Grapefruit Juice: May increase the serum concentration of HMG-CoA Reductase Inhibitors.
Management
Consider avoiding concurrent use of GFJ (especially larger amounts) with lovastatin, simvastatin, or atorvastatin. Consider using a lower statin dose or a statin that is less likely to interact when possible.

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