Lovastatin vs Gemfibrozil

Interacting Drugs
Lovastatin
vs
Gemfibrozil
Security Level
Moderate, Consider therapy modification
Mechanism
Gemfibrozil: May enhance the myopathic (rhabdomyolysis) effect of Lovastatin. Gemfibrozil may increase the serum concentration of Lovastatin. More specifically, gemfibrozil may increase the serum concentrations of lovastatin acid (active form of parent drug).
Management
If possible, avoid concomitant use of lovastatin and gemfibrozil or consider using micronized fenofibrate instead of gemfibrozil. If gemfibrozil use can not be avoided, limit lovastatin to 20 mg/day and closely monitor for signs of rhabdomyolysis.

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