Lovastatin vs Cyproterone

Interacting Drugs
Lovastatin
vs
Cyproterone
Security Level
Moderate, Consider therapy modification
Mechanism
Cyproterone: May increase the serum concentration of HMG-CoA Reductase Inhibitors.
Management
Avoid use of statins metabolized by CYP3A4 (eg, simvastatin) and consider avoiding fluvastatin as well in patients receiving high dose cyproterone (300 mg/day). Consider use of pravastatin, rosuvastatin, or pitavastatin if statin therapy is needed.

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