Lansoprazole, amoxicillin, and clarithromycin vs Zidovudine

Interacting Drugs
Lansoprazole, amoxicillin, and clarithromycin
vs
Zidovudine
Security Level
Moderate, Consider therapy modification
Mechanism
Zidovudine: Clarithromycin may enhance the myelosuppressive effect of Zidovudine. Clarithromycin may decrease the serum concentration of Zidovudine.
Management
Monitor response to zidovudine closely when used with clarithromycin, and consider staggering zidovudine and clarithromycin doses when possible in order to minimize the potential for interaction.

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