Lansoprazole, amoxicillin, and clarithromycin vs Pimozide

Interacting Drugs
Lansoprazole, amoxicillin, and clarithromycin
vs
Pimozide
Security Level
Major, Avoid combination
Mechanism
Pimozide: Macrolide Antibiotics may enhance the QTc-prolonging effect of Pimozide. Macrolide Antibiotics may decrease the metabolism of Pimozide. QTc prolongation is a risk.
Management
Avoid combination

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