Lansoprazole, amoxicillin, and clarithromycin vs Mesalamine

Interacting Drugs
Lansoprazole, amoxicillin, and clarithromycin
vs
Mesalamine
Security Level
Moderate, Consider therapy modification
Mechanism
Mesalamine: Proton Pump Inhibitors may diminish the therapeutic effect of Mesalamine. Proton pump inhibitor-mediated increases in gastrointestinal pH may cause the premature release of mesalamine from specific sustained-release mesalamine products.
Management
Consider avoiding concurrent administration of high-dose proton pump inhibitors (PPIs) with sustained-release mesalamine products.

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