Lansoprazole, amoxicillin, and clarithromycin vs Maraviroc

Interacting Drugs
Lansoprazole, amoxicillin, and clarithromycin
vs
Maraviroc
Security Level
Moderate, Consider therapy modification
Mechanism
Maraviroc: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Maraviroc.
Management
Reduce the adult dose of maraviroc to 150 mg twice daily when used with a strong CYP3A4 inhibitor. Do not use maraviroc with strong CYP3A4 inhibitors in patients with Clcr less than 30 mL/min.

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