Ketorolac (systemic) vs Sodium Phosphates

Interacting Drugs
Ketorolac (systemic)
vs
Sodium Phosphates
Security Level
Moderate, Consider therapy modification
Mechanism
Sodium Phosphates: May enhance the nephrotoxic effect of Nonsteroidal Anti-Inflammatory Agents. Specifically, the risk of acute phosphate nephropathy may be enhanced.
Management
Consider avoiding this combination by temporarily suspending treatment with NSAIDs, or seeking alternatives to oral sodium phosphate bowel preparation. If the combination cannot be avoided, maintain adequate hydration and monitor renal function closely.

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