Ioxilan vs MetFORMIN

Interacting Drugs
Ioxilan
vs
MetFORMIN
Security Level
Moderate, Consider therapy modification
Mechanism
MetFORMIN: Iodinated Contrast Agents may enhance the adverse/toxic effect of MetFORMIN. Renal dysfunction that may be caused by iodinated contrast agents may lead to metformin-associated lactic acidosis.
Management
Withhold metformin from all patients receiving intravascular iodinated contrast agents prior to or at the time of the procedure and for at least 48 hrs thereafter. Document adequate renal function before restarting metformin.

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