Hydrochlorothiazide and spironolactone vs Eplerenone

Interacting Drugs
Hydrochlorothiazide and spironolactone
vs
Eplerenone
Security Level
Moderate, Consider therapy modification
Mechanism
Eplerenone: May enhance the hyperkalemic effect of Potassium-Sparing Diuretics.
Management
This combination is contraindicated in patients receiving eplerenone for treatment of hypertension.

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