Haloperidol vs ChlorproMAZINE

Interacting Drugs
Haloperidol
vs
ChlorproMAZINE
Security Level
Moderate, Consider therapy modification
Mechanism
ChlorproMAZINE: May enhance the QTc-prolonging effect of Haloperidol. Haloperidol may increase the serum concentration of ChlorproMAZINE. ChlorproMAZINE may increase the serum concentration of Haloperidol.
Management
Consider alternatives to combined treatment with these agents. If combined treatment cannot be avoided, monitor for signs and symptoms of prolonged QTc interval (e.g. arrhythmias).

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