Fluoxetine vs Dextromethorphan

Interacting Drugs
Fluoxetine
vs
Dextromethorphan
Security Level
Moderate, Consider therapy modification
Mechanism
Dextromethorphan: Selective Serotonin Reuptake Inhibitors may enhance the serotonergic effect of Dextromethorphan. Selective Serotonin Reuptake Inhibitors may increase the serum concentration of Dextromethorphan.
Management
Avoid the concurrent use of dextromethorphan and SSRIs, particularly fluoxetine and paroxetine, when possible. The risk for this interaction may persist for several weeks following discontinuation of fluoxetine or paroxetine.

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Other Interactions of Fluoxetine

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Other Interactions of Dextromethorphan

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