Fluoxetine vs Atomoxetine

Interacting Drugs
Fluoxetine
vs
Atomoxetine
Security Level
Moderate, Consider therapy modification
Mechanism
Atomoxetine: CYP2D6 Inhibitors (Strong) may increase the serum concentration of Atomoxetine.
Management
Initiate atomoxetine at a reduced dose (adult doses -- patients up to 70kg: 0.5mg/kg/day; patients 70kg or more: 40mg/day) in patients receiving a strong CYP2D6 inhibitor.

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